When Rose suffers terrible injuries in a motorcycle crash, she is taken to a nearby clinic run by Dr Keloid for experimental skin-graft surgery. At first, the revolutionary procedure proves successful, but it soon leaves Rose with a strange orifice protruding from her armpit and an insatiable thirst for human blood. Hell-bent on satisfying her bloodlust, Rose leaves a trail of insane and uncontrollably aggressive victims, as the unknown virus engulfs North America in an orgy of frenetic violence.